Annual report [Section 13 and 15(d), not S-K Item 405]

Organization and Description of Business (Details Narrative)

v3.25.1
Organization and Description of Business (Details Narrative)
3 Months Ended 12 Months Ended
Jul. 25, 2024
USD ($)
shares
Jul. 17, 2024
USD ($)
Jun. 14, 2024
USD ($)
May 20, 2024
$ / shares
shares
May 14, 2024
USD ($)
Apr. 05, 2024
USD ($)
$ / shares
Mar. 31, 2024
USD ($)
Feb. 23, 2024
Feb. 14, 2024
shares
Feb. 13, 2024
shares
Nov. 13, 2023
USD ($)
Jun. 07, 2023
USD ($)
$ / shares
shares
Feb. 21, 2023
USD ($)
$ / shares
shares
Dec. 31, 2024
USD ($)
$ / shares
shares
Sep. 30, 2024
USD ($)
Jun. 30, 2024
USD ($)
Mar. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
$ / shares
shares
Sep. 30, 2023
USD ($)
Jun. 30, 2023
USD ($)
Mar. 31, 2023
USD ($)
Dec. 31, 2024
USD ($)
$ / shares
shares
Dec. 31, 2023
USD ($)
$ / shares
shares
Jul. 24, 2024
$ / shares
shares
Jun. 17, 2024
shares
Mar. 04, 2024
$ / shares
Feb. 28, 2023
$ / shares
shares
Dec. 31, 2022
USD ($)
Common stock, par value | $ / shares                           $ 0.001       $ 0.001       $ 0.001 $ 0.001 $ 0.001   $ 0.001    
Reverse stock split               1-for-30 1-for-30 reverse stock split                                      
Common stock issued | shares                 16,666,666 500,000,000                                    
Common stock, shares authorized | shares 250,000,000               66,666,666 550,000,000       250,000,000       250,000,000       250,000,000 250,000,000 16,666,666        
Preferred stock, par value | $ / shares                           $ 0.001       $ 0.001       $ 0.001 $ 0.001          
Issuance of preferred shares   $ 5,100,000                                                
Preferred stock dividends                                           2,927,803 4,218,213          
Derivative fair value                         $ 3,149,800 $ 0               0            
Stock issuance costs                                           314,311            
Fair value of the warrants                                           10,623,000            
Change in fair value of the derivative liabilities                                           $ (388,000) 3,088,800          
Probability of default                           3.6               3.6            
Fair value of the warrants                                           10,623,000          
Issuance of warrants                                           762,834            
Warrants at fair value                                           4,410,000 (9,756,000)          
Preferred stock dividends                                           315,410            
Fair value of the bifurcated embedded derivative                           $ 1,303,000       $ 61,000       $ 1,303,000 $ 61,000          
Preferred stock, shares authorized | shares                           50,000,000       50,000,000       50,000,000 50,000,000          
Option to purchase shares | shares                                                      
Exercise price | $ / shares                                                      
Option to purchase shares                                           $ 1,057,271 $ 3,049,537          
Employment agreement description                     Effective November 13, 2023, the Company entered into an amendment to the employment agreement of Dr. Chris Chapman, its President and Chief Medical Officer, providing for Dr. Chapman’s annual base salary to be adjusted from five hundred thousand dollars ($500,000) (the “Full Base Salary”) to two hundred fifty thousand dollars ($250,000) in cash per annum, until payment of his Full Base Salary would no longer jeopardize the Company’s ability to continue as a going concern, as determined by the Company in its sole discretion. The amendment further provides that the remaining $250,000 of base salary per annum (the “Deferral Amount”) shall be deferred until payment of the Deferral Amount would no longer jeopardize the Company’s ability to continue as a going concern, as determined by the Company in its sole discretion, at which time the Deferral Amount may be paid, at Dr. Chapman’s election, in shares of Common Stock or in cash. As of December 31, 2024 and December 31, 2023, the Company had recognized a salary deferral of $149,038 and $28,846, respectively, which was paid to Dr. Chapman on June 27, 2024.                                  
Officers compensation                                           476,563 944,834          
Implementation of directors agreement description                     In connection with an overall reduction in compensation paid to the Company’s directors implemented in November 2023, effective November 13, 2023, the Company entered into an amendment to the employment agreement of Christopher C. Schreiber, a Director and the Company’s former Executive Chairman, providing for Mr. Schreiber’s annual fee to be adjusted from three hundred thousand dollars ($300,000) (the “Full Fee”) to sixty thousand dollars ($60,000) in cash per annum, until payment of his Full Fee would no longer jeopardize the Company’s ability to continue as a going concern, as determined by the Company in its sole discretion. The amendment further provides that the remaining $240,000 of the fees per annum (the “Fee Deferral Amount”) shall be deferred until payment of the Fee Deferral Amount would no longer jeopardize the Company’s ability to continue as a going concern, as determined by the Company in its sole discretion, at which time the Fee Deferral Amount may be paid, at Mr. Schreiber’s election, in shares of Common Stock or in cash. The amendment also clarified that Mr. Schreiber’s title is “Director.” As of December 31, 2024 and 2023, the Company had recognized a salary deferral of $175,385 and $27,692, respectively, which was paid to Mr. Schreiber on August 22, 2024.                                  
Deferred Compensation Payable [Member]                                                        
Board fee deferral                           $ 209,800       $ 44,000       $ 209,800 44,000          
Series F-1 Short Term Warrants [Member]                                                        
Warrant exercise price | $ / shares                           $ 1.816               $ 1.816            
Warrants to purchase common stock | shares                           2,780,839               2,780,839            
Series F-1 Long Term Warrants [Member]                                                        
Warrant exercise price | $ / shares                           $ 1.816               $ 1.816            
Warrants to purchase common stock | shares                           2,780,839               2,780,839            
Warrants at fair value $ 6,965,000                                                      
Change in fair value as a non-cash loss 6,000                                                      
Change in fair value as a non-cash loss                                           $ 968,000            
Series G Short-Term Warrants [Member]                                                        
Warrants at fair value 12,343,000                                                      
Change in fair value as a non-cash loss $ 11,000                                                      
Change in fair value as a non-cash loss                                           1,716,000            
Fair Value, Recurring [Member]                                                        
Change in fair value of the derivative liabilities                           $ 21,000 $ 356,000 $ 72,000 $ (61,000) (837,100) $ (2,566,900) $ 194,500 $ 120,700              
Warrants at fair value                             17,000 (2,701,000) 7,094,000   (5,356,000) (1,635,000) (1,175,000)              
Reclassification of warrant liability to equit upon warrant modification                             (19,308,000)   (7,961,000)                      
Fair value of the bifurcated embedded derivative                         $ 1,303,000 $ 1,282,000 $ 926,000 $ 61,000 $ 898,100 $ 3,465,000 $ 3,270,500 1,303,000 61,000        
Other Operating Income (Expense) [Member]                                                        
Change in fair value of the derivative liabilities                                           $ 61,000 $ 3,088,800          
Fair value of common stock on valuation date | $ / shares                           $ 1.15               $ 1.15            
Common Stock [Member]                                                        
Common stock issued | shares                                             65,960          
Issuance of preferred shares                                                    
Exercise price | $ / shares                           $ 1.15       $ 7.77       $ 1.15 $ 7.77          
Preferred Stock [Member]                                                        
Issuance of preferred shares                                           $ 14,087,111            
Derivative fair value                           $ 3,149,800               $ 3,149,800            
Contra Preferred Stock [Member]                                                        
Issuance of preferred shares   9,000,000.0                                                    
Minimum [Member]                                                        
Common stock, shares authorized | shares                                               16,666,666        
Maximum [Member]                                                        
Common stock, shares authorized | shares                                               250,000,000        
Maximum [Member] | Common Stock [Member]                                                        
Preferred stock conversion ratio percentage                           19.99               19.99            
Measurement Input, Expected Dividend Rate [Member]                                                        
Derivative measurement input                         10.0 10.0               10.0            
Estimated equity volatility                                           105.00%            
Discounted market interest rate                                           6.00%            
Penalty dividend rate                           15.0               15.0            
Measurement Input, Exercise Price [Member] | Common Stock [Member]                                                        
Exercise price | $ / shares                         $ 1.90 $ 1.15               $ 1.15            
Measurement Input, Option Volatility [Member]                                                        
Derivative measurement input                         120.0                              
Measurement Input, Price Volatility [Member]                                                        
Derivative measurement input                         190.0                              
Measurement Input, Maturity [Member]                                                        
Time of maturity                         1 year 4 months 6 days                              
Measurement Input, Maturity [Member] | Other Operating Income (Expense) [Member]                                                        
Time of maturity                                           6 months            
Measurement Input, Discount Rate [Member]                                                        
Derivative measurement input                         6.8                              
Measurement Input, Lapse Rate [Member]                                                        
Derivative measurement input                         15.0                              
Measurement Input, Default Rate [Member]                                                        
Derivative measurement input                         0.5                              
Measurement Input Volume Volatility [Member]                                                        
Estimated traded volume volatility                           320.0               320.0            
Series F Warrants [Member]                                                        
Fair value of the warrants                                           $ 7,961,000            
Series F Warrants [Member] | Fair Value, Recurring [Member]                                                        
Warrant liability         $ 7,961,000   7,094,000                                          
Reclassification of warrant liability to equit upon warrant modification             $ 7,961,000                                          
Series F Warrants [Member] | Other Operating Income (Expense) [Member]                                                        
Warrants at fair value                                           $ 7,094,000 $ 9,756,000          
Series F Warrants [Member] | Warrant [Member]                                                        
Warrants term                           3 years 10 months 24 days               3 years 10 months 24 days            
Series F Warrants [Member] | Measurement Input, Option Volatility [Member]                                                        
Stock price per share                           110.0               110.0            
Series F Warrants [Member] | Measurement Input, Expected Dividend Payment [Member]                                                        
Stock price per share                           0               0            
Series F Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member]                                                        
Stock price per share                           4.31               4.31            
Series F Convertible Preferred Stock [Member]                                                        
Conversion price | $ / shares                         $ 2.255                              
Share issued price, per share | $ / shares           $ 6.765                                            
Issuance of preferred shares           $ 3,000,000                                            
Preferred shares dividend rate                         10.00%                 10.00%            
Preferred stock conversion ratio percentage                           19.99               19.99            
Series F Convertible Preferred Stock [Member] | Preferred Stock [Member]                                                        
Issuance of preferred shares                                           912,889          
Series F Convertible Preferred Stock [Member] | Minimum [Member]                                                        
Conversion price | $ / shares                         $ 60.21 $ 60.21               $ 60.21            
Series F Convertible Preferred Stock [Member] | Measurement Input, Expected Dividend Rate [Member]                                                        
Preferred shares dividend rate                         15.00%                              
Series F Convertible Preferred Stock [Member] | Measurement Input, Default Rate [Member]                                                        
Preferred shares dividend rate                                           15.00%            
Series F-1 Preferred Stock [Member]                                                        
Warrant exercise price | $ / shares                           $ 1.816               $ 1.816            
Debt description                                           The amortization payments due upon such redemption are payable, at the Company’s election, in cash, or subject to certain limitations, in shares of Common Stock valued at the lower of (i) the Series F Conversion Price then in effect and (ii) the greater of (A) 80% of the average of the three lowest closing prices of the Company’s Series F Common Stock during the thirty trading day period immediately prior to the date the amortization payment is due or (B) a “Floor Price” of $6.60 on a post-split basis (subject to adjustment for stock splits, stock dividends, stock combinations, recapitalizations or other similar events) or, in any case, such lower amount as permitted, from time to time, by the Nasdaq Stock Market.            
Preferred shares dividend rate                                           10.00%            
Change in fair value of the derivative liabilities                                           $ 449,000            
Warrants at fair value                                           7,900,000            
Estimated fair value of preferred stock                                           9,300,000            
Derivative liability                           $ 900,000               900,000            
Stock discount                                           $ 5,100,000            
Preferred stock stock description                                           (i) approximately $4.2 million related to the difference between the gross proceeds and the allocated residual fair value of the Series F-1 Preferred Stock (i.e., $0), and (ii) approximately $0.9 million related to the stock derivative at issuance, is accounted for as a reduction to the carrying value of the Series F Preferred Stock and will be accreted from the issuance date to maturity in accordance with ASC 480-10-S99-3A as redemption is deemed probable pursuant to the Installment Redemption terms of the Series F-1 Certificate of Designations.            
Fair value of the bifurcated embedded derivative                           $ 1,303,000               $ 1,303,000            
Series F-1 Preferred Stock [Member] | Minimum [Member]                                                        
Conversion price | $ / shares                           $ 2.253               $ 2.253            
Series F-1 Preferred Stock [Member] | Measurement Input, Expected Dividend Rate [Member]                                                        
Preferred shares dividend rate                                           15.00%            
Derivative measurement input                           10.0               10.0            
Series F-1 Preferred Stock [Member] | Measurement Input, Option Volatility [Member]                                                        
Derivative measurement input                           105.0               105.0            
Series F-1 Preferred Stock [Member] | Measurement Input, Price Volatility [Member]                                                        
Derivative measurement input                           320.0               320.0            
Series F-1 Preferred Stock [Member] | Measurement Input, Maturity [Member]                                                        
Time of maturity                                           6 months            
Series F-1 Preferred Stock [Member] | Measurement Input, Discount Rate [Member]                                                        
Derivative measurement input                           7.0               7.0            
Series F-1 Preferred Stock [Member] | Measurement Input, Lapse Rate [Member]                                                        
Derivative measurement input                           15.0               15.0            
Series F-1 Preferred Stock [Member] | Measurement Input, Default Rate [Member]                                                        
Derivative measurement input                           3.6               3.6            
Series G Preferred Stock [Member]                                                        
Preferred shares dividend rate                                           10.00%            
Preferred stock dividends                                           $ 559,393            
Series G Preferred Stock [Member] | Preferred Stock [Member]                                                        
Warrants at fair value   14,100,000                                                    
Estimated fair value of preferred stock   $ 22,300,000                                                    
Series G Preferred Stock [Member] | Minimum [Member]                                                        
Common stock, shares authorized | shares                                                 8,950      
Conversion price | $ / shares                           $ 2.253               $ 2.253            
Series G Preferred Stock [Member] | Maximum [Member]                                                        
Common stock, shares authorized | shares                                                 12,826,273      
Series G Preferred Stock [Member] | Measurement Input, Expected Dividend Rate [Member]                                                        
Preferred shares dividend rate                                           15.00%            
Series F Common Stock Warrants [Member]                                                        
Fair value of the warrants                                           $ 10,623,000            
Series F Common Stock Warrants [Member] | Warrant [Member]                                                        
Warrants term                           5 years               5 years            
Series F Common Stock Warrants [Member] | Measurement Input, Option Volatility [Member]                                                        
Stock price per share                           125.0               125.0            
Series F Common Stock Warrants [Member] | Measurement Input, Expected Dividend Payment [Member]                                                        
Stock price per share                           0               0            
Series F Common Stock Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member]                                                        
Stock price per share                           4.09               4.09            
Series F One Preferreds Stock [Member]                                                        
Debt description                                           The amortization payments due upon such redemption are payable, at the Company’s election, in cash at 105% of the applicable Installment Redemption Amount (as defined in the Series F-1 Certificate of Designations), or subject to certain limitations, in shares of Common Stock valued at the lower of (i) the Series F-1 Conversion Price then in effect and (ii) the greater of (A) 80% of the average of the three lowest closing prices of the Company’s Common Stock during the thirty consecutive trading day period ending and including the trading day immediately prior to the date the amortization payment is due or (B) $0.364, which is 20% of the “Minimum Price” (as defined in Nasdaq Stock Market Rule 5635) on the date in which the Series F-1 Stockholder Approval (as defined herein) was obtained or, in any case, such lower amount as permitted, from time to time, by the Nasdaq Capital Market, and, in each case, subject to adjustment for stock splits, stock dividends, stock combinations, recapitalizations or other similar events, which amortization amounts are subject to certain adjustments as set forth in the Series F-1 Certificate of Designations (the “Series F-1 Floor Price”).            
Series G Convertible Preferred Stock [Member] | Preferred Stock [Member]                                                        
Issuance of preferred shares                                                    
Investors [Member] | Warrant [Member] | Series G Short-Term Warrants [Member]                                                        
Warrant exercise price | $ / shares                           $ 1.816               $ 1.816            
Warrants to purchase common stock | shares                           4,928,416               4,928,416            
Investors [Member] | Warrant [Member] | Series G Warrants [Member]                                                        
Warrant exercise price | $ / shares                           $ 1.816               $ 1.816            
Warrants to purchase common stock | shares                           4,928,416               4,928,416            
Employees Options [Member]                                                        
Option to purchase shares | shares                       7,668                                
Exercise price | $ / shares                       $ 49.80                                
Option to purchase shares                       $ 168,496                                
Director [Member]                                                        
Deferral excess payment                     $ 156,000                                  
Director [Member] | Minimum [Member]                                                        
Director fees                     60,000                                  
Director [Member] | Maximum [Member]                                                        
Director fees                     216,000                                  
Eagle Uzonwanne [Member]                                                        
Deferral excess payment                     36,000                                  
Eagle Uzonwanne [Member] | Minimum [Member]                                                        
Director fees                     60,000                                  
Eagle Uzonwanne [Member] | Maximum [Member]                                                        
Director fees                     $ 96,000                                  
Securities Purchase Agreement [Member]                                                        
Shares issued | shares       5,050                                                
Issuance of warrants | shares       2,780,839                                                
Warrant exercise price | $ / shares       $ 1.816                                                
Securities Purchase Agreement [Member] | Series F-1 Short Term Warrants [Member]                                                        
Issuance of warrants | shares       2,780,839                                                
Warrant exercise price | $ / shares       $ 1.816                                                
Securities Purchase Agreement [Member] | Series F-1 Long Term Warrants [Member]                                                        
Issuance of warrants | shares       2,780,839                                                
Warrant exercise price | $ / shares       $ 1.816                                                
Securities Purchase Agreement [Member] | Series F-1 Preferred Stock [Member]                                                        
Preferred stock, par value | $ / shares       0.001                                                
Preferred stock, stated value | $ / shares       1,000                                                
Securities Purchase Agreement [Member] | Series G Preferred Stock [Member]                                                        
Preferred stock, par value | $ / shares       0.001                                                
Preferred stock, stated value | $ / shares       $ 1,000                                                
Securities Purchase Agreement [Member] | Investors [Member]                                                        
Shares issued | shares                         15,000                              
Preferred stock stated value                         $ 1,000                              
Issuance of warrants | shares                         6,651,885                              
Warrant exercise price | $ / shares                         $ 2.255                           $ 3.18  
Warrants to purchase common stock | shares                         4,716,904                           4,716,904  
Preferred stock, par value | $ / shares                         $ 3.18                              
Warrant exercise price | $ / shares                         $ 3.18                              
Convertible shares issuable | shares                         8,259,911                           8,259,911  
Conversion price | $ / shares                         $ 1.816                              
Warrants term                                                     5 years  
Securities Purchase Agreement [Member] | Investors [Member] | Series G Short-Term Warrants [Member]                                                        
Issuance of warrants | shares       4,928,416                                                
Warrants to purchase common stock | shares       4,928,416                                                
Warrant exercise price | $ / shares       $ 1.816                                                
Securities Purchase Agreement [Member] | Investors [Member] | Series G Long-Term Warrants [Member]                                                        
Issuance of warrants | shares       4,928,416                                                
Warrant exercise price | $ / shares       $ 1.816                                                
Warrants to purchase common stock | shares       4,928,416                                                
Securities Purchase Agreement [Member] | Investors [Member] | Common Stock [Member]                                                        
Warrants to purchase common stock | shares                                                     4,716,904  
Securities Purchase Agreement [Member] | Investors [Member] | Series F Warrants [Member]                                                        
Warrants to purchase common stock | shares                         6,651,885                              
Securities Purchase Agreement [Member] | Investors [Member] | Series F Preferred Stock [Member]                                                        
Warrant exercise price | $ / shares                         $ 1.816                              
Preferred stock, par value | $ / shares                         1.816                              
Securities Purchase Agreement [Member] | Investors [Member] | Series G Preferred Stock [Member]                                                        
Shares issued | shares       8,950                                                
Issuance of warrants | shares       4,928,416                                                
Warrant exercise price | $ / shares       $ 1.816                 $ 1.816                              
Conversion price | $ / shares                           $ 1.816               $ 1.816            
Securities Purchase Agreement [Member] | Investors [Member] | Series F Common Stock Warrants [Member]                                                        
Warrant exercise price | $ / shares                                                     $ 1.816  
Amendment Agreement [Member] | Series G Convertible Preferred Stock [Member] | Minimum [Member]                                                        
Preferred stock, shares authorized | shares                                                 8,950      
Amendment Agreement [Member] | Series G Convertible Preferred Stock [Member] | Maximum [Member]                                                        
Preferred stock, shares authorized | shares                                                 12,826,273      
Series F-1 Registration Rights Agreement [Member]                                                        
Series F-1 registration rights description                                           the Company entered into a Registration Rights Agreement with the Series F-1 Investors (the “Series F-1 Registration Rights Agreement,”), pursuant to which the Company agreed to file a resale registration statement (the “Series F-1 Registration Statement”) with the SEC to register for resale (A) 200% of the Series F-1 Conversion Shares and (B) 200% of the Series F-1 Warrant Shares promptly following the Closing Date, but in no event later than 30 calendar days after the Closing Date, and to have such Series F-1 Registration Statement declared effective by the Effectiveness Deadline (as defined in the Series F-1 Registration Rights Agreement).            
Series G Registration Rights Agreement [Member]                                                        
Series F-1 registration rights description                                           the Company entered into a Registration Rights Agreement with the Series G Investors (the “Series G Registration Rights Agreement” and, together with the Series F-1 Registration Rights Agreement, the “Registration Rights Agreements”) pursuant to which the Company agreed to file a resale registration statement (the “Series G Registration Statement”) with the SEC to register for resale (A) 200% of the Series G Conversion Shares, (B) 200% of the shares of Common Stock issuable upon conversion of the PIK Shares, and (C) 200% of the Series G Warrant Shares promptly following the Closing Date, but in no event later than 30 calendar days after the Closing Date, and to have such Series G Registration Statement declared effective by the Effectiveness Deadline (as defined in the Series G Registration Rights Agreement).            
Gpn agreement [Member] | Series F Warrants [Member]                                                        
Private placement warrants description                                           In connection with the Private Placements, pursuant to (A) an engagement letter (the “GPN Agreement”) with GP Nurmenkari Inc. (“GPN”) and (B) an engagement letter (the “Palladium Agreement,” and collectively with the GPN Agreement, the “Engagement Letters”) with Palladium Capital Group, LLC (“Palladium,” and collectively with GPN, the “Placement Agents”), the Company engaged the Placement Agents to act as non-exclusive placement agents in connection with each Private Placement, pursuant to which, the Company agreed to (i) pay the Placement Agents a cash fee equal to 3% of the gross proceeds of each Private Placement (including any cash proceeds realized by the Company from the exercise of the Series F Warrants), (ii) reimbursement and payment of certain expenses, and (iii) issue to the Placement Agents on the Closing Date, warrants to purchase up to an aggregate of 693,833 of shares of Common Stock to each Placement Agent, which is equal to 3% of the aggregate number of shares of Common Stock underlying the securities issued in each Private Placement, including upon exercise of any Series F Warrants, with terms identical to the Series G Long-Term Warrants and Series F-1 Long-Term Warrants.            
Separation Agreement [Member]                                                        
Officers compensation     $ 125,000                                                  
Payments to officer     $ 25,000                                                  
Salaries                                           $ 150,000            
Share based compensation                                           $ 197,427